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Brivanib alaninate
CAS No. 649735-63-7
Brivanib alaninate ( BMS-582664;BMS 582664;BMS582664 )
产品货号. M15466 CAS No. 649735-63-7
A prodrug of Brivanib, which is a dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥656 | 有现货 |
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| 5MG | ￥948 | 有现货 |
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| 10MG | ￥1701 | 有现货 |
|
| 25MG | ￥3038 | 有现货 |
|
| 50MG | ￥4957 | 有现货 |
|
| 100MG | ￥7898 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Brivanib alaninate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A prodrug of Brivanib, which is a dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively.
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产品描述A prodrug of Brivanib, which is a dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively; exhibits improved aqueous solubility and oral bioavailability of the parent compound.Liver Cancer Phase 3 Clinical
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同义词BMS-582664;BMS 582664;BMS582664
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通路Angiogenesis
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靶点VEGFR
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受体FGFR1;Flk1;VEGFR1;VEGFR2
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研究领域Cancer
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适应症Liver Cancer
化学信息
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CAS Number649735-63-7
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分子量441.46
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分子式C22H24FN5O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OCC(C)OC(=O)C(C)N)C
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化学全称L-Alanine, (1R)-2-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-1-methylethyl ester
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cai ZW, et al. J Med Chem. 2008 Mar 27;51(6):1976-80.
2. Huynh H, et al. Clin Cancer Res. 2008 Oct 1;14(19):6146-53.
3. Patel RR, et al. Eur J Cancer. 2010 Jun;46(9):1537-53.
2. Huynh H, et al. Clin Cancer Res. 2008 Oct 1;14(19):6146-53.
3. Patel RR, et al. Eur J Cancer. 2010 Jun;46(9):1537-53.
产品手册
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